Macrolide lactams
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 10mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
![Medchemexpress LLC (+)-(R)-[(E)-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acryloyl]-2-piperidineethanol | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244110.png-250.jpg)
Medchemexpress LLC (+)-(R)-[(E)-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acryloyl]-2-piperidineethanol | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 50 MG
FK 453 is a non-xanthine adenosine A1 receptor antagonist (compound 1d) used in pharmacological research. It is reported as potent and selective, with an IC50 of 17.2 nM. The compound has chemical formula C23H25N3O2, molecular weight 375.46, and reported purity 99.20%.
- Potent and selective A1 receptor antagonist (IC50 17.2 nM).
- High reported purity suitable for research use (99.2%).
- Chemical formula C23H25N3O2 and molecular weight 375.46.
- Available in small research quantities, for example 50 mg.
- Supplied with supporting analytical data such as COA, HPLC, and LCMS.
AdipoGen Ascomycin high purity
Chemical. CAS 104987-12-4. Formula C43H69NO12. MW 792. Isolated from Streptomyces sp. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin protein phosphatase 2B PP2B. Suppresses the production of T helper type 1 Th1 interferon and IL-2 and Th2 IL-4 and IL-10 cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant antiepileptic.
Medchemexpress LLC D-alanine, N-((R)-6-carboxy-N2-(N-(1-oxoheptyl)-D-gamma-glutamyl)-L-lysyl)- | 79335-75-4 | ≥98.0% | 502.57 g/mol | C22H38N4O9 | 5mg
FK-565 is a nucleotide oligomerization domain-1 (NOD1) ligand FK-565 induces murine model with arteritis[1]
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 1g
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
TARGETMOL CHEMICALS INC Ascomycin 500MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. Purity 99.94%
AdipoGen Ascomycin high purity
Chemical. CAS 104987-12-4. Formula C43H69NO12. MW 792. Isolated from Streptomyces sp. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin protein phosphatase 2B PP2B. Suppresses the production of T helper type 1 Th1 interferon and IL-2 and Th2 IL-4 and IL-10 cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant antiepileptic.
Medchemexpress LLC E/Z-FK-506 26,28-allylic ester rearrangement impurity | 131944-48-4 | >90.0% | 804.02 | C44H69NO12 | 10 MG
(E/Z)-FK-506 26,28-allylic ester rearrangement impurity (FK506-A) is an impurity of tacrolimus used as a reference standard for analytical and stability studies. It is intended for research and analytical applications to identify, quantify, and qualify impurity profiles; consult the certificate of analysis for storage and handling details.
- Reference impurity of tacrolimus for analytical method development.
- Suitable for impurity identification, reporting, and qualification studies.
- High-purity material for reliable chromatographic and mass spectrometric analysis (>90.0%).
- Supplied as a solid for laboratory use; consult the certificate of analysis for storage instructions.
- Molecular formula C44H69NO12 and molecular weight 804.02 for compound identification.
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 10mM (in 1mL DMSO), CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Selleck Chemical LLC Tacrolimus monohydrate
Tacrolimus monohydrate (Tacrolimus FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) This inhibition blocks calcium-dependent processes including interleukin-2 gene transcription nitric oxide synthase activation cell degranulation and apoptosis and also has immunosuppressive neuroregenerative and neuroprotective properties
Medchemexpress LLC Tacrolimus (FK506) | 104987-11-3 | MFCD00869853 | 99.6% | 803.48 Da | C44H69NO12 | 5 MG
Tacrolimus (FK506) analytical standard intended for research and analytical applications. Tacrolimus is a macrolide immunosuppressant that binds FK506 binding protein and inhibits calcineurin, affecting T-lymphocyte signal transduction. This reference material is supplied for assay calibration, method development, and quality control in analytical workflows.
- High-purity reference material (99.6%).
- Intended for analytical and research use, including assay calibration and method development.
- Available in small mass quantities suitable for analytical workflows (e.g., 5 mg).
- Provides a stable, characterized standard for quality control.
- Supplied with documentation for purity and identity.
Selleck Chemical LLC Tacrolimus monohydrate
Tacrolimus monohydrate (Tacrolimus FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) This inhibition blocks calcium-dependent processes including interleukin-2 gene transcription nitric oxide synthase activation cell degranulation and apoptosis and also has immunosuppressive neuroregenerative and neuroprotective properties
Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | MFCD11045918 | 99.9% | 822.03 g·mol⁻¹ | C44H71NO13 | 5 MG
Tacrolimus monohydrate is a macrocyclic lactone immunosuppressant reagent that binds FK506 binding protein (FKBP) and inhibits calcineurin phosphatase, suppressing T-cell signaling and IL-2 transcription for in vitro immunology and biochemical studies.
- High purity suitable for research applications.
- Molecular formula C44H71NO13; molecular weight 822.03 g·mol⁻¹.
- CAS number 109581-93-3 for unambiguous identification.
- Store protected from light at 4°C; in solution store at -80°C for long-term stability.
- Commonly used in assays targeting calcineurin and FKBP-mediated pathways.
![Medchemexpress LLC (E)-1-[(2R)-2-(2-hydroxyethyl)piperidin-1-yl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243908.png-250.jpg)
Medchemexpress LLC (E)-1-[(2R)-2-(2-hydroxyethyl)piperidin-1-yl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 10 MG
FK 453 is a potent, selective adenosine A1 receptor antagonist intended for research use. It inhibits human A1 receptor activity with an IC50 of 17.2 nM, appears as an off-white to light yellow solid, and also shows activity at adenosine A2B and in primary rat hepatocytes.
- Potent adenosine A1 receptor antagonist (IC50 17.2 nM).
- Additional activity at adenosine A2B (cAMP accumulation IC50 0.98 μM).
- Inhibits NECA-induced glucose production in primary rat hepatocytes (IC50 8.1 μM).
- High purity: 99.2%.
- Molecular weight: 375.46.
- Off-white to light yellow solid; soluble in DMSO (100 mg/mL).
- Storage recommendations: powder -20°C (3 years); in solvent -80°C (6 months).
Medchemexpress LLC Tacrolimus/BSA | 1 MG
Tacrolimus/BSA is an antigen-adjuvant conjugate formed by conjugating Tacrolimus with Bovine Serum Albumin (BSA). This conjugation enhances the production of antigen-specific antibodies in vaccine models. It does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
- Enhances production of antigen-specific antibodies
- Does not affect protein folding
- Does not disrupt major epitopes
- Enhances cross-presentation
- Generates antigen-specific T cells