Macrolide lactams
Medchemexpress LLC Tacrolimus 8-epimer | 129212-35-7 | MFCD27967171 | 5mg
Tacrolimus anhydrous 8-epimer (Tacrolimus EP impurity D) is a l-pipecolic acid macrolide lactone an important immunosuppressive agent that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines especially IL-2[1]
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 50mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models